Which of the following statements is true concerning ceruloplasmin?

Which of the following statements is true concerning ceruloplasmin?

• A. It decreases in liver failure.
• B. It is unaltered in inflammatory diseases.
• C. It binds to serum iron.
• D. It shows increased levels in acute phase reactions.

Answer: (D)

Ceruloplasmin is a copper-carrying protein that plays a crucial role in iron metabolism. It functions as a ferroxidase, which means it helps oxidize ferrous ions (Fe2+) to ferric ions (Fe3+), facilitating the binding of iron to transferrin for transport in the blood. In the context of acute phase reactions, ceruloplasmin is known to be an acute phase reactant. This means that during inflammatory states or tissue damage, its levels in the serum typically increase. This rise is due to the liver's response to inflammation, where it produces more proteins that help in managing the body's response to injury or infection. Therefore, observing increased levels of ceruloplasmin during such conditions is consistent with its role as an acute phase protein. Recognizing these properties of ceruloplasmin is valuable in clinical laboratory settings, particularly when evaluating inflammatory diseases or conditions related to copper and iron metabolism. Thus, the statement indicating that ceruloplasmin shows increased levels in acute phase reactions is accurate and aligns with known physiological responses.

Ceruloplasmin is a copper-carrying protein that plays a crucial role in iron metabolism. It functions as a ferroxidase, which means it helps oxidize ferrous ions (Fe2+) to ferric ions (Fe3+), facilitating the binding of iron to transferrin for transport in the blood.

In the context of acute phase reactions, ceruloplasmin is known to be an acute phase reactant. This means that during inflammatory states or tissue damage, its levels in the serum typically increase. This rise is due to the liver's response to inflammation, where it produces more proteins that help in managing the body's response to injury or infection. Therefore, observing increased levels of ceruloplasmin during such conditions is consistent with its role as an acute phase protein.

Recognizing these properties of ceruloplasmin is valuable in clinical laboratory settings, particularly when evaluating inflammatory diseases or conditions related to copper and iron metabolism. Thus, the statement indicating that ceruloplasmin shows increased levels in acute phase reactions is accurate and aligns with known physiological responses.